Dogs that suffer hyperthermia (high body temperature secondary to multiple etiologies) are at high risk of devastating seizures, disseminated intravascular coagulopathy, and cardiac events during transport or while being prepared for intensive care. The overall objective of this research was to assess the effectiveness of using hemo-acupuncture (HA) as an effective intervention treatment for timely relief of hyperthermia in dogs. The study involved 26 dogs with hyperthermia (body temperature >103.5°F). Each subject was randomly assigned into a test or control group. Dogs in the Test Group were treated with HA at Er-jian, Shan-gen, and Wei-jian acupoints using a 25-gauge syringe needle. Bloodletting of at least 1-3 drops was observed. The Control Group was treated with a single intravenous injection of meloxicam at the standard IV dose of 0.2 mg per kg. Among the 12 control subjects, 9 of 12 dogs had reduced temperatures within 20 minutes after treatment with a mean±SD reduction of 0.94±0.66°F. Findings for the 14 test subjects demonstrated reduced temperatures after treatment in 14 of 14 dogs with a mean±SD reduction of 2.09±0.74°F. This reduction was more than double (ratio=2.22) that in the Control Group. The results of this data support the hypothesis that HA treatment is at least as effective as meloxicam injection in reducing body temperature in dogs with hyperthermia and in fact the mean maximal temperature reduction within 20 minutes after receiving treatment in the Test Group was significantly greater than that in the Control Group (p = 0.00045).