Gastrointestinal stasis (ileus) is a common problem of rabbits, causing economic and personal loss within the rabbit industry. Mu Bing Xiao Huang, containing 60% Mang Xiao (Mirabilitum), 20% Da Huang (Rheum), 10% Mu Xiang (Saussurea) and 10% Bing Lang (Areca), has been used in China since the 1600s to stimulate peristalsis. Although there are case studies on effectiveness, controlled experimental research is needed. To study the effects of Mu Bing Xiao Huang and component herbs, the authors designed an in-vitro experiment of 15 groups of rabbit jejunal muscle preparations (15-18 samples each) and an in-vivo experiment of 30 rabbits with artificially induced intestinal intussusceptions. In the in-vitro experiment, Mu Bing Xiao Huang produced a 95% increase in intestinal muscle contraction amplitudes, compared to a 3%-74% increase for single ingredient herbs. In the in-vivo experiment, the M±SD intussusception resolution time, after the topical administration of Mu Bing Xiao Huang on exposed ileums was 3.55±2.05 and the saline control was 19.65±7.57 minutes (only 2 rabbits resolved intussusceptions), very significantly different at (p<0.01). The M±SD intussusception resolution time of 5 vagotomized rabbits after topical administration of Mu Bing Xiao Huang was 3.42±2.02 minutes, not significantly different from nonvagotomized rabbits, but intravenous administration significantly reduced (p<0.05) the resolution time (2.32±1.28 minutes). Based on the positive effects demonstrated in this study, further studies of Mu Bing Xiao Huang are warranted to conclusively support the use of Mu Bing Xiao Huang as evidence-based medicine to stimulate peristalsis in rabbits and other species.