A classical Chinese herbal medicine, Wu Mei Wan, was used to treat horses affected with equine metabolic syndrome (EMS) with concurrent laminitis and/or uveitis associated with a pattern in Chinese medicine known as Jue Yin syndrome. Twentyfour EMS patients with concurrent laminitis (16/24) or uveitis (4/24) or both presentations (4/24) that were poorly responsive or unresponsive to conventional treatments were enrolled. All horses were orally medicated with Wu Mei Wan for 30 days. Horses with laminitis, received baseline scores (0-5) before treatment followed by weekly scores until study termination. Horses with uveitis were assessed by the degree of eye opening at the same time points (0 fully open to 4 tightly shut). Successful treatment outcome for either condition, was at least 50% improvement (with respect to the clinical assessment score) by the end of the 4-week study. All 20 horses with laminitis had improved lameness scores after 1 week of treatment (mean score 3.85 ±0.88 reduced to 1.2 ±1.11) with percent mean reduction among subjects of 69.8%, 81.2%, 93.8% and 97.1% after 1, 2, 3, and 4 weeks of treatment, respectively. All 8 uveitis subjects had improved scores after 1 week (mean score 3.25 ±0.89 reduced to 0.625 ±0.74) and mean reduction of 80.2%, 86.5% after 1 and 2 weeks of treatment, respectively. The response rate for both laminitis and uveitis was 100% (50% improvement, week 4) with all p-values < 0.001. Study results suggest that the Chinese herbal medicine, Wu Mei Wan, may be an effective treatment for unresponsive cases of laminitis and/ or uveitis associated Jue Yin and equine metabolic syndromes.