Two hundred 124-day-old Laifeng hens were randomly divided into four equal groups. All hens were fed the same poultry feed, but in Groups 1-3, 0.5%, 1.5% and 2% Chinese herbal medicine (CHM) respectively was added to the feed. Group 4 (Control Group) received no CHM. The CHM was a proprietary blend of eight herbs: 1) Shi Gao (Gypsum), 2) Chai Hu (Bupleurum), 3) Bai Zhu (Atractylodes), 4) Bai Shao (Paeonia), 5) Gan Cao (Glycyrrhiza), 6) Bu Gu Zhi (Psoralea), 7) Bo He (Mentha) and 8) Fu Ling (Poria) formulated to tonify the Spleen, Kidney and Blood, clear Heat and calm Shen. The mean±standard deviation of the total number, weights and production rates of eggs, New Castle’s disease virus serum antibodies and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) oxidative enzymes were calculated for each group and compared using a Duncan Multiple Comparison test. A significant difference was established as p<0.05 and a very significant difference was p<0.01. The egg numbers and production rate, serum antibody titers for NDV and SOD levels were significantly or very significantly higher and the MDA levels significantly lower in Groups 1-3 compared to Group 4 (Control group). Group 1 (0.5% CHM) had best overall effect on egg production and Group 3 (2% CHM) had best effect on vaccine response. The addition of CHM to the feed had significant positive effects on egg production, immune function and oxidative stress indicators and may be an effective replacement for conventional drugs in poultry production