An 8 year old, 32 kg neutered male Standard Poodle was presented for severe sterile hemorrhagic cystitis secondary to
cyclophosphamide administration for small cell lymphoma. In addition to the discontinuation of cyclophosphamide, the
patient was treated with a combination of a nonsteroidal anti-inflammatory drug, acupuncture, and Chinese herbal Xiao Ji
Yin Zi (Cephalanoplos Decoction; Red Front Door). Clinical signs of cystitis resolved by 3 months; however the patient
was euthanatized 8 months after presentation due to progressive lymphoma. This case report documents successful
treatment of cyclophosphamide associated cystitis in a dog utilizing an integrated therapeutic approach.