The efficacy of integrating the Chinese herbal medicine, Yin Qiao San (YQS), with doxycycline compared to doxycycline alone for treating feline upper respiratory infection (URI) was investigated. Thirty-five cats exhibiting clinical signs of URI were randomly assigned to the Control or Test groups. All cats received 5 mg/kg dose of doxycycline. The Test Group additionally received YQS (dosed 50-100 mg/kg). All treatments were given twice daily for 10 days. Based on a 10-parameter URI clinical sign scoring system, improvement during the treatment period was analyzed. A subject was considered recovered from URI when scoring 0s on all signs for three consecutive days. Those who did not recover within 10 days continued having clinical sign scores assessed until recovery. In the Test Group, the mean recovery time was 9.3±3.6 days, which was significantly shorter (p=0.008) than the Control Group (14.0±6.0 days). The proportion of subjects recovered within 2 weeks was 94% (16/17) in the Test Group, which was significantly greater (p=0.002) than that in the Control Group (8/18=44%). Polymerase chain reaction (PCR) testing was performed to determine pathogens present on Day 1. The two most common pathogens identified were feline herpesvirus-1 and Mycoplasma felis. No cat tested positive for influenza A or influenza H7N2. Co-infection with more than 1 pathogen was present in 22% of controls and 41% of the Test Group. These findings suggest that integrating YQS with doxycycline resulted in quicker recovery than doxycycline alone when treating cats suffering from feline infectious respiratory disease complex.