Gui Pi Tang (Restore the Spleen Decoction) is a renowned blood tonic used to treat Heart (Blood) and Spleen (Qi) deficiencies. The original source of the formula is from the Ji Sheng Fang (Formulas to Aid the Living) by Yan Yong- He in 1253. The original formula of Gui Pi Tang is composed of the following individual herbs: 6 g Ren Shen (Radix et Rhizoma Ginseng), 12 g Huang Qi (Radix Astragali), 9 g Bai Zhu (Rhizoma Atractylodis Macrocephalae), 3 g Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata), 9 g Dang Gui (Radix Angelicae Sinensis), 12 g Long Yan Rou (Arillus Longan), 9 g Fu Shen (Poria Pararadicis), 12 g Yuan Zhi (Radix Po.lygalae), 12 g Suan Zao Ren (Semen Ziziphi Spinosae), and 6 g Mu Xiang (Radix Aucklandiae). The Chinese therapeutic actions of this formula are to tonifiy Qi and Blood, strengthen the Spleen and nourish the Heart. A review of clinical signs improved by use of this herbal formula, as well as research and species dosing is presented in this article.