Between 2006-2015, 67 dogs were presented with Grade II-IV patellar luxation/subluxation. Study animals were given a novel Chinese herbal medicine called HipGuard, a proprietary blend of 24 ingredients, at a dose of 0.5 grams per 15 pounds and no other treatment. The dogs were monitored for lameness, pain and joint stability with cases followed by physical examination for an average of 4 years (45.24±16.98 months). Age, gender, body weight, breed, pre-treatment disease duration and requirement for long-term herbal treatment were compared between responsive and non-responsive categories. Clinical soundness was achieved in 66/67 (98.5%) of the study dogs. Stabilization (stopping abnormal movement of the stifle by encouraging periarticular fibroplasia) occurred in 51 of 67 (76.1%) cases or 88 of 108 joints affected (81.5%). Partial stabilization occurred in 12 of 67 cases (17.9%) and 4 of 67 dogs (6%) did not achieve joint stabilization but were clinically sound by study completion. The average time to resolution of lameness/pain for both stabilization and non-stabilization groups was 10.2 weeks and average time to patellar stability was 10.7 months. The administration of HipGuard, for canine patella luxation resulted in statistically significant improvement of joint function and pain, p<0.001 (Chi square test). No dog had a severe reaction to the herbal medication or dropped out of the study due to adverse effects. This study demonstrated that the Chinese herbal medicine, HipGuard, can be a safe and effective treatment for dogs with patellar luxation disease and can provide an alternative to surgery and conventional medical management.