A 16-year-old draft mule mare presented with a 5-week history of blindness. The onset had been acute with the inciting event unidentified. Diagnostic workup at the University of Florida School of Veterinary Medicine (VTH) had identified a mass, located caudal to the ethmoturbinates and impinging on the optic nerves, with magnetic resonance imaging (MRI). Differential diagnoses included ethmoid hematoma, granuloma of unknown cause (including fungal and parasitic), abscess, and benign or malignant neoplasia. A specific diagnosis could not be obtained via conventional Western medical methods due to the location of the lesion which precluded surgical removal, biopsy or further diagnostic testing to conclusively identify the mass. The mule had failed to realize sustained clinical recovery of normal vision following several weeks of treatment with dexamethasone and propranolol at the VTH clinic. A poor prognosis had been given for stable recovery of vision due to the inaccessible location and unidentifiable nature of the lesion. Utilizing the principles of traditional Chinese veterinary medicine (TCVM), a Pattern diagnosis of local Blood Stagnation of the optic nerves, and Qi Stagnation resulting in the clinical sign of blindness, was established during the TCVM clinical exam. Using a combination of acupuncture, Chinese herbal medicine and Tui-na, the patient’s vision was restored bilaterally, and she was able to resume her normal activities as part of a draft team used to pull wagons on a hunting plantation. This case is one of many examples which illustrate that even, or especially, in those instances when a definitive diagnosis eludes conventional medical procedures, the diagnostic principles and treatment tools of TCVM can be effectively applied to restore the health of many veterinary patients.